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Lead investigator Jack Cuzick, professor and head of the Centre for Cancer Prevention at Queen Mary University of London, describes the trial as an "exciting development" in the prevention of breast cancer, and adds: "We now know anastrozole should be the drug of choice when it comes to reducing the risk of breast cancer in post-menopausal women with a family history or other risk factors for the disease. This class of drugs is more effective than previous drugs such as tamoxifen and crucially, it has fewer side effects." He suggests that concerns about side effects for this type of drug, such as acute aches and pains, may have been overstated in the past, since the side effects reported in their study were only slightly higher in the anastrozole than the placebo group.
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He says the priority should now be to ensure as many women as possible benefit from these new findings, adding that: "Prevention is an important tool in the fight against breast cancer and we strongly urge the National Institute for Health and Care Excellence (NICE) to consider adding anastrozole to their recommended drugs for women who are predisposed to developing breast cancer."
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Kate Law, Cancer Research UK's director of clinical research, says: "We now need accurate tests that will predict which women will most benefit from anastrozole and those who will have the fewest side effects." The charity has been funding the IBIS II trial for over 10 years. Prof. Cuzick was also on a panel that published a review about the future of breast cancer prevention in Lancet Oncology in March 2011. The panel agreed that all women with a higher than 4% above average risk of getting breast cancer in the next 10 years should be offered preventive measures and close monitoring.

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