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"We need to better understand other possible factors, since the prior tamoxifen factor could be a false lead from an unplanned analysis," says Mehta, who is eager to see whether even more patients might benefit from this combination treatment. "The next step for researchers," she says, "would be to try the combination in even earlier stages of breast cancer to test whether long-term cures could be increased at those stages."
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A large landmark study funded by Cancer Research UK has found that the breast cancer drug anastrozole can halve the chances of developing the disease in high-risk women. The results of the IBIS II trial, led by Queen Mary University of London and published online in the The Lancet this week, show that in nearly 4,000 post-menopausal women at high risk of breast cancer, taking anastrozole for 5 years cut cases by 53%, compared with a placebo. The researchers note that this amount of reduction is more effective than tamoxifen and the results also showed fewer side effects from anastrozole.
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Anastrozole, an aromatase inhibitor, stops the body making estrogen, a hormone that fuels the growth of many breast cancers. It has been in use for many years as a treatment for post-menopausal women with estrogen receptor positive breast cancer. The women were aged 40-70 years and came from 18 countries. Half were randomly assigned to a daily dose of 1 mg of anastrozole, and half to a daily dose of placebo. "Double-blind" means neither the women nor the health care professionals treating them knew whether they were given placebo or the active drug. Over a median follow-up of 5 years, 40 (2%) participants in the anastrozole group developed breast cancer, compared with 85 (4%) in the placebo group.

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